Extracellular vesicles and the placenta–brain axis: mechanisms of shared risk in pregnancy and perinatal psychiatry

Key Points

• Shared risk mechanisms involve extracellular vesicles, affecting both pregnancy and mental health outcomes.
• Findings highlight the role of inflammation and biomarkers across the placenta-brain axis in perinatal psychiatry.
• Analysis across multiple research approaches underscores the intertwined relationship between pregnancy complications and psychiatric conditions.
• Understanding these mechanisms may enable targeted interventions for improving maternal and infant mental health.