Umbilical cord mesenchymal stem cell-derived exosomes delivered via a thermosensitive hydrogel ameliorate atopic dermatitis by mitigating keratinocyte mitochondrial damage through activating the Wnt/β-catenin pathway | Synapse
March 3, 2026
Umbilical cord mesenchymal stem cell-derived exosomes delivered via a thermosensitive hydrogel ameliorate atopic dermatitis by mitigating keratinocyte mitochondrial damage through activating the Wnt/β-catenin pathway
Key Points
Exosomes derived from umbilical cord stem cells significantly reduce keratinocyte mitochondrial damage in atopic dermatitis.
The treatment group shows a 30% improvement in symptoms compared to controls over 4 weeks.
Assessment using a thermosensitive hydrogel for exosome delivery indicates high bioavailability and sustained release.
This approach may enable better management of atopic dermatitis pending clinical validation in larger populations.