Enhanced sono-radio dynamic therapy of non-small cell lung cancer using a polydopamine coated manganese dioxide-gold nanosystem: reactive oxygen species amplification and tumor microenvironment modulation

Key Points

• Enhanced sono-radio dynamic therapy significantly improves therapeutic outcomes against non-small cell lung cancer.
• Reactive oxygen species amplification is critical for maximizing tumor cell damage, particularly in oxygen-poor settings.
• Assessment using a polydopamine coated manganese dioxide-gold nanosystem shows effectiveness in modulating the tumor microenvironment.
• Highlighting the potential for improved treatment strategies, these findings support further investigations into nanotechnology applications.