March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Arsenic trioxide-induced acute kidney injury: OPA1- and Drp1-mediated mitochondrial dynamics imbalance, PINK1/Parkin-dependent mitophagy, and Chuanhuang Fang III

Key Points

Acute kidney injury is linked to an imbalance in mitochondrial dynamics and impaired mitophagy.
Mitochondrial dynamics are mediated by OPA1 and Drp1, affecting cellular quality control.
PINK1 and Parkin play crucial roles in mitophagy in renal tubular epithelial cells during injury.
Chuanhuang Fang III may restore mitochondrial quality control, suggesting a potential treatment.

Abstract

The pathogenesis of clinical-dose ATO-induced AKI involves OPA1- and Drp1-mediated mitochondrial dynamics imbalance and PINK1/Parkin-dependent mitophagy in renal tubular epithelial cells, CHF ameliorated this injury by restoring mitochondrial quality control, highlighting its therapeutic potential against AI-AKI.

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