A shark VNAR-IL-15 fusion protein that suppresses TROP2+ tumor growth

Key Points

• Tumor growth suppression occurs following the application of VNAR-IL-15, demonstrating significant effects on TROP2+ tumors.
• A notable reduction in tumor size was observed, indicating a strong therapeutic effect with the fusion protein.
• Analysis revealed that the VNAR-IL-15 effectively binds to TROP2, enhancing immune response against the tumors.
• The findings suggest further exploration of VNAR-IL-15 as a promising candidate in cancer immunotherapy.