Rational design of 2-substituted thio-7-chloroquinazolin-4(3H)-one derivatives as dual EGFR/VEGFR-2 inhibitors with broad-Spectrum anticancer and apoptotic activities

Key Points

• Dual inhibitors showed significant anticancer and apoptotic activities, targeting EGFR and VEGFR-2.
• The novel thio-7-chloroquinazolin-4(3H)-one derivatives were synthesized and tested for efficacy.
• Evaluations involved assessing cell viability and apoptosis in various cancer cell lines under specific conditions.
• The findings support the potential of these compounds in developing new cancer therapies.