TLR4/NF-κB signaling-mediated neuroinflammation is associated with gut microbiota dysbiosis in a mouse model of Parkinson’s disease

Key Points

• Neuroinflammation correlates significantly with gut microbiota dysbiosis in a mouse model of Parkinson's disease.
• Key findings reveal a deep connection between TLR4/NF-κB signaling and gut microbiota disturbances when triggered by rotenone.
• Assessment of the microbiota-gut-brain axis shows how inflammatory signaling pathways affect neurological health.
• Therapeutic implications suggest targeting TLR4/NF-κB pathways to potentially alleviate Parkinson's disease symptoms.