Synthesis, characterization of novel 2-methoxy-6-((3-substituted-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)iminomethyl)phenyl 4-methylbenzoates and their molecular docking parameters with acetylcholinesterase and butyrylcholinesterase: an in silico mechanism and ADMET investigation

Key Points

• New compounds demonstrate inhibition of acetylcholinesterase and butyrylcholinesterase.
• Synthesis involved 2-methoxy-6-((3-substituted-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)iminomethyl)phenyl 4-methylbenzoates.
• Molecular docking studies reveal binding interactions with key enzymes, supporting their potential against Alzheimer's.
• ADMET profiling suggests favorable properties, but further in vivo validation is necessary.