Time-dependent alterations in brain metabolites and gut microbiota following whole-brain FLASH versus conventional radiotherapy in mice

Key Points

• Brain metabolites significantly change following radiotherapy, particularly with FLASH.
• FLASH radiotherapy led to distinct alterations in gut microbiota compared to conventional approaches.
• Observational analysis reveals insights into the effects of two different radiotherapy methods in mice.
• Findings may inform future strategies for enhancing radiotherapy effectiveness, though mouse model limits apply.