Altered gene expression associated with Alzheimer's disease in the SH-SY5Y neuroblastoma cell model: Enhanced intracellular GSK3β and Cyclophilin A, as key neuropathology-inducing factors

Key Points

• Enhanced levels of gsk3β and cyclophilin a correlate with Alzheimer's neuropathology.
• The study highlights significant changes in gene expression in a neuroblastoma cell model relevant to Alzheimer's.
• This analysis utilizes SH-SY5Y cells to investigate the effects of specific proteins on neurodegenerative pathways.
• Findings indicate that gsk3β and cyclophilin a may play critical roles in cellular mechanisms associated with Alzheimer's.