Uridine diphosphate drives myeloid differentiation and functional reprogramming through dynamic transcriptional network

Key Points

• UDP restricts monocyte proliferation, enabling their differentiation into dendritic-like cells with improved phagocytic abilities.
• The study highlights that UDP engages complex transcriptional programs that connect innate and adaptive immunity.
• Findings demonstrate that UDP may contribute to immune homeostasis and the regulation of inflammation in the body.
• Potential implications include enhancing our understanding of how metabolites affect immune responses and therapies.

Abstract