Sequential glucose hypometabolism in the progression of Alzheimer's disease

Key Points

• Glucose hypometabolism is associated with significant neurodegeneration in Alzheimer's disease.
• Key biomarkers indicate a progressive decline in glucose utilization in a longitudinal cohort.
• This analysis used metabolic pathway assessments to track disease changes across varying stages of Alzheimer's.
• These findings highlight the potential for targeted interventions early in the metabolic decline of Alzheimer's.