Clinicopathological features of mismatch repair-deficient colorectal cancer: an observational experience from Romagna, Italy

Key Points

• Mismatch repair deficiency associates with unique clinicopathological features.
• Key tumor characteristics include notable alterations in tumor microenvironment and mutation burden.
• Observational analysis across Romagna, Italy reveals insights into clinicopathological characteristics.
• Highlights need for targeted strategies in diagnosis and management of colorectal cancer.