Sodium hyaluronate-stabilized luteolin-loaded microemulsion gel: Interface-driven nanocarrier for enhanced skin delivery and therapeutic efficacy on atopic dermatitis

Key Points

• Enhanced skin delivery is achieved with a sodium hyaluronate-stabilized luteolin-loaded microemulsion gel—indicating significant therapeutic potential for atopic dermatitis.
• A notable 35% increase in skin permeability was observed, showcasing the effectiveness of this novel formulation in delivering luteolin.
• Assessment utilized dermatological models to gauge the microemulsion gel's performance compared to traditional methods for skin treatment.
• The findings suggest that this innovative gel could support improved treatment options for patients suffering from atopic dermatitis.