Differential effects of pregabalin and morphine on the sleep-wake cycle and circadian rhythms in mice with neuropathic pain

Key Points

• Differential effects on the sleep-wake cycle indicate distinct mechanisms between pregabalin and morphine.
• Pregabalin treatment reduced nocturnal activity by 30% compared to morphine in modeled neuropathic pain.
• Evaluation was done using a mouse model of neuropathic pain with a focus on circadian rhythms.
• Findings highlight the importance of drug selection in managing sleep disturbances associated with pain.