Dose Heterogeneity in Transarterial Radioembolization after Fractional Administration of Holmium Microspheres: A Study in Perfused Human Tumor-Bearing Liver Explants under MR Imaging

Key Points

Dose heterogeneity impacts both liver tumors and surrounding nontumor regions, complicating treatment assessments.
Fine-scale distributions reveal variability below standard imaging resolution, indicating potential clinical concerns.
This observational analysis uses human tumor-bearing liver explants subjected to MR imaging to assess microsphere behavior.
Further investigation is needed to fully understand the clinical relevance of these findings on treatment efficacy.

Abstract

TARE induces heterogeneous dose distributions in both liver tumors and nontumor target liver at a scale below the resolution of nuclear imaging. Although these findings provide insight into microsphere distribution and dose heterogeneity, the clinical significance of fine-scale dose heterogeneity and its potential impact on treatment outcomes remains uncertain and warrants further investigation.

Dose Heterogeneity in Transarterial Radioembolization after Fractional Administration of Holmium Microspheres: A Study in Perfused Human Tumor-Bearing Liver Explants under MR Imaging

Key Points

Abstract

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