Multimodal rapid anti-depression: Esketamine combined with dexmedetomidine patient-controlled sleep for treatment-resistant depression — A retrospective study

Key Points

• Patients experienced significant relief from treatment-resistant depression symptoms with a combination of esketamine and dexmedetomidine.
• The study documented a notable improvement of depression scores over a defined follow-up period, highlighting efficacy.
• Retrospective analysis examined historical patient data from those who received the multimodal intervention successfully.
• These findings support the potential of combined therapies in managing challenging depression cases, warranting further exploration.