Deregulation of a phosphorylation-dependent normal function of tau in mitochondrial reverse electron transport drives tauopathies

Key Points

• Deregulated phosphorylation impairs normal tau function, leading to mitochondrial dysfunction.
• This study identifies a connection between tau and mitochondrial reverse electron transport in disease progression.
• Deep analysis of cellular mechanisms highlights tau's role in energy metabolism and cellular health.
• Findings may enable strategies to target tau for treating tauopathies, though clinical translations are needed.