Harnessing phenothiazine-imidazole small molecules for 20s proteasome activation: A new paradigm for treating neurodegenerative diseases with transcriptomic analysis

Key Points

• Proteasome activation is enhanced with phenothiazine-imidazole small molecules, indicating a breakthrough in treatment.
• Findings show a 30% increase in proteasome activity, showcasing the efficacy of these small molecules.
• Transcriptomic analysis was employed to investigate cellular responses to proteasome activation.
• This approach may enable better therapeutic strategies for neurodegenerative diseases, yet further validation is essential.