Conditional T and NK cell antagonism by a giant and highly conserved orthopoxvirus virulence factor

Key Points

• Cell antagonism mediated by the orthopoxvirus virulence factor highlights a significant immune evasion strategy.
• The study reveals that both T cells and NK cells are affected, indicating broad implications for cellular immunity.
• Observational analysis reveals a highly conserved virulence factor across different orthopoxviruses.
• Implications suggest potential new avenues for therapies targeting viral evasion tactics.