Apelin-13 induces lordosis behavior in estradiol-primed ovariectomized rats via the activation of multiple protein kinases in the ventromedial hypothalamus

Key Points

• Lordosis behavior is significantly induced by apelin-13 in ovariectomized rats, indicating its role in reproductive behaviors.
• Key evidence shows a notable activation of multiple protein kinases in the ventromedial hypothalamus affecting this behavior.
• This study conducted an observational analysis focusing on the hormonal influence of estradiol with respect to apelin-13 administration.
• Findings highlight the complex interplay of hormonal and neurobiological factors influencing reproductive behaviors, warranting further exploration.