Optimal Pharmacokinetic Sampling Strategy for Melphalan-Based Conditioning Prior to Allogeneic Hematopoietic Stem Cell Transplantation

Key Points

• Improved pharmacokinetic sampling enhances conditioning outcomes for melphalan before transplantation.
• Optimal sampling strategy shows a reduced variation in drug exposure, indicating better management.
• Assessment of melphalan dosing utilized pharmacokinetic profiling in transplant patients.
• These findings may support personalized approaches to drug administration in hematopoietic stem cell transplantation.