Astragalus polysaccharide enhances the antitumor efficacy of sunitinib in renal cell carcinoma by targeting the ZEB1-SCD1-Wnt/β-Catenin signaling pathway

Key Points

• Astragalus polysaccharide significantly increases the antitumor efficacy of sunitinib in renal cell carcinoma.
• The study highlights the specific targeting of the ZEB1-SCD1-Wnt/β-catenin signaling pathway as a critical mechanism.
• Assessment using cell line models demonstrates profound synergistic effects in tumor growth inhibition with combined treatment.
• These findings may suggest a promising therapeutic strategy to enhance cancer treatment outcomes, with further research needed for clinical validation.