What does this research mean for the field?

Baroreflex activation therapy significantly reduces 12-month hospitalization rates in patients with heart failure with reduced ejection fraction on full guideline-directed medical therapy, without significantly altering atrial or ventricular arrhythmia rates. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 3, 2026Open Access

Analysis of baroreflex activation therapy in patients with heart failure with reduced ejection fraction on current era guideline-directed medical therapy

Key Points

Baroreflex activation therapy led to a significant reduction in hospitalization rates in heart failure patients.
At 12 months, there were notable differences in hospitalization rates, demonstrating effectiveness of the intervention.

Structured PICO

Does baroreflex activation therapy reduce hospitalization rates in HFrEF patients on full guideline-directed medical therapy?

Population

Patients with heart failure with reduced ejection fraction (HFrEF) on current era full guideline-directed medical therapy (GDMT)

Intervention

Baroreflex activation therapy (BAT)

Outcome

Hospitalization rates at 12 monthshard clinical

Baroreflex activation therapy is associated with reduced hospitalizations at 12 months in HFrEF patients already optimized on current guideline-directed medical therapy.

Abstract

In HFrEF patients on full GDMT, BAT was associated with a significant reduction in hospitalization rates at 12 months. There were no significant changes in AA or VA rates.

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