Tumor cell derived CCL20 exacerbates the immunosuppressive microenvironment by recruiting CCR6+ Tregs in pancreatic cancer

Key Points

• Tregs, or regulatory T cells, increase due to CCL20, creating an immunosuppressive environment.
• The study indicates that CCL20 may be pivotal in recruiting CCR6+ Tregs in pancreatic cancer.
• Assessment identifies the role of tumor-derived CCL20 in modifying the tumor microenvironment.
• Findings highlight the need for targeted therapies against CCL20 to improve pancreatic cancer outcomes.