A Neurotoxicity Mimic: Progressive Multifocal Leukoencephalopathy Following BCMA-Directed CART and Bispecific Therapies

Key Points

• Multifocal leukoencephalopathy occurs as a neurotoxic effect, impacting patient outcomes significantly.
• Key evidence includes a notable increase in neurological symptoms in patients undergoing BCMA-directed CART.
• Assessment using clinical data revealed the association between BCMA-directed CART and neurotoxicity manifestations.
• The findings highlight the urgent need for careful monitoring during and after BCMA-directed CART treatments.