Screening strategy using a filamentous fungus model to repurpose drugs for mitochondrial complex I deficiencies | Synapse
March 3, 2026Open Access
Screening strategy using a filamentous fungus model to repurpose drugs for mitochondrial complex I deficiencies
Key Points
Promising therapeutic candidates for mitochondrial complex I diseases were identified using a fungal model.
Podospora anserina was utilized to screen potential drug repurposing strategies effectively.
This research advances the understanding of mitochondrial complex I deficiencies and therapeutic options.
Implications for clinical trials could transform treatment approaches for impacted patients.
Abstract
Together, our work demonstrates the usefulness of Podospora anserina as fungal model for identifying promising therapeutic candidates for complex I diseases, paving the way for future clinical trials.