Our work has established the first human iRPE models to study the effects of peroxisome dysfunction in the RPE. Impaired peroxisome activity resulted in significant lipid profile changes and defective phagocytosis in iRPE. Dysregulated POS metabolism in the RPE is a potential mechanism driving retinal degeneration in patients with PBDs. Fully understanding the role of peroxisomes in the RPE will facilitate the development of novel therapies for degenerative retinal disorders.
Building similarity graph...
Analyzing shared references across papers
Loading...
Constantin Mouzaaber
University of Alberta
Carly B. Feldman
National Institutes of Health
Suzette M Huguenin
Kennedy Krieger Institute
University of Michigan
National Institutes of Health
University of Alberta
Building similarity graph...
Analyzing shared references across papers
Loading...
Mouzaaber et al. (Tue,) studied this question.
synapsesocial.com/papers/69a76070c6e9836116a2d302 — DOI: https://doi.org/10.64898/2026.02.01.701576