Efficient and Simplified Identification of CCR5Δ32-Mutated Cord Blood Units for HIV-Positive Transplant Candidates

Key Points

• CCR5Δ32 mutations may enhance graft acceptance in HIV-positive patients, improving outcomes.
• Approximately 10% of cord blood units showed the CCR5Δ32 mutation, indicating viable donor options.
• Analysis of cord blood units utilized genome sequencing techniques to detect mutations efficiently.
• This approach may support better selection processes in HIV gene therapy using cord blood.