The Role of Pentamidine for Pneumocystis Jirovecii Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis

Key Points

• Pentamidine prophylaxis significantly reduces Pneumocystis jirovecii infections in recipients of hematopoietic stem cell transplantation, leading to better overall health outcomes.
• The analysis reveals an infection rate decrease of approximately 30% among those receiving pentamidine compared to those who do not.
• This comprehensive meta-analysis combines data from several studies, focusing on patients undergoing allogeneic stem cell transplantation during their post-operative care phase.
• Findings may highlight the necessity for consistent Pneumocystis jirovecii prophylaxis in similar transplant settings to protect vulnerable populations.