Dose-dependent biphasic reversal of ABC transporter–mediated multidrug resistance by natural dihydrochalcone via P-glycoprotein suppression

Key Points

• This study shows a biphasic effect in reversing multidrug resistance under varying doses of dihydrochalcone.
• Key evidence indicated significant effects on drug absorption at two different dosage levels, highlighting a promising therapeutic avenue.
• Dose-dependent effects were assessed on ABC transporters, particularly observing P-glycoprotein suppression mechanisms involved.
• Results suggest potential for dihydrochalcone in overcoming cancer therapies, although further research is needed on its practical application.