Orai1- and STIM1-mediated calcium signaling controls PD-L1 expression and modulates antitumor immunity in oral cancer

Key Points

• Calcium signaling regulates PD-L1 expression, leading to altered antitumor immunity.
• Key evidence shows a direct link between Orai1 and STIM1 calcium signaling and PD-L1 levels.
• Analysis of calcium signaling pathways illustrates their role in immune modulation and tumor adaptation.
• These findings highlight potential therapeutic targets in oral cancer based on calcium-mediated processes.