Mechanistic insights into the hepatic metabolism of lentinan: A TLR2–ROS–lysosome axis

Key Points

• Hepatic metabolism of lentinan is influenced by the TLR2–reactive oxygen species pathway, enhancing immune response.
• Increased reactive oxygen species levels were observed in the presence of lentinan, suggesting a mechanistic link to metabolism.
• Analysis of hepatotoxicity mechanisms indicates that the lysosomal pathway plays a crucial role in cellular processing of lentinan.
• Understanding these pathways may lead to therapeutic advancements targeting immune modulation through hepatic metabolism.