ANKFY1 suppresses PDCoV replication by degrading viral nsp8 protein via p62-dependent selective autophagy

Key Points

• PDCoV replication is suppressed via degradation of nsp8 by ANKFY1, enhancing viral clearance.
• Key evidence shows that ANKFY1 effectively targets nsp8, potentially reducing infection rates significantly.
• Analysis utilizes p62-dependent selective autophagy to illustrate the degradation pathway of the viral protein.
• This work highlights potential avenues for antiviral development against PDCoV; further clinical validation may be required.