Impact of Severe Infections on Non-Relapse Mortality after Allogeneic HCT: A Post-Hoc Analysis of a Randomized Phase II Study Comparing Post-Transplantation Cyclophosphamide (PTCy) and Non-Ptcy-Based GVHD Prophylaxis

Key Points

• Severe infections significantly increase non-relapse mortality rates in allogeneic HCT patients, indicating their critical impact on outcomes.
• The study specifically reveals a concerning trend where infections contribute to worsening mortality despite prophylactic measures used.
• Observational analysis of a randomized phase II trial comparing post-transplantation cyclophosphamide and non-PTCy-based GVHD prophylaxis was conducted.
• These findings highlight the need to develop better strategies for preventing severe infections post-transplant, as they may lead to higher mortality rates.