Structure-Based Drug Design of Sanguinarine Derivatives Targeting Babesia microti Lactate Dehydrogenase through Computational Approaches

Key Points

• Targeting lactate dehydrogenase, sanguinarine derivatives show promise against Babesia microti.
• Computational approaches identified specific derivatives that might effectively inhibit the enzyme.
• Structure-based drug design techniques allowed for the optimization of compound selection based on binding affinity.
• Further validation is needed to confirm the efficacy of these derivatives against Babesia microti in vivo.