Myocardial cell-derived exosomal miR-155-5p promotes depressive disorders in CVD via microglial SIRT1 pathway

Key Points

• Depressive disorders are associated with the miR-155-5p pathway in cardiovascular disease.
• The change in SIRT1 levels was statistically significant in this context, supporting a potential target for treatment.
• Analysis of exosomes from myocardial cells demonstrated their crucial role in the development of depressive symptoms.
• These findings highlight the need for further research to explore therapeutic options targeting the SIRT1 pathway.