SUCNR1-driven microglial polarization: Jiawei Xionggui decoction as a therapeutic strategy for Alzheimer’s-related neuroinflammation

Key Points

• SUCNR1-driven microglial polarization may play a crucial role in Alzheimer's-related neuroinflammation, and thus presents a therapeutic target.
• In laboratory tests, Jiawei Xionggui decoction demonstrated significant effects on neuroinflammatory markers associated with Alzheimer's disease.
• This assessment analyzed microglial activity and various mediators connected to neuroinflammation in Alzheimer's pathology.
• Findings may support integrating traditional Chinese medicine into approaches for managing neuroinflammation in Alzheimer's disease.