Dolabellane diterpenes with angiogenic activity from the soft coral Clavularia koellikeri collected in the South China sea

Key Points

• The dolabellane diterpenes exhibit significant angiogenic activity, promoting blood vessel formation.
• Key bioassays demonstrate their impact on vascular endothelial cells with a specific focus on proliferation and migration.
• Analysis of marine natural products from Clavularia koellikeri reveals previously unknown compounds with biological activity.
• Potential therapeutic implications highlight new avenues for treating conditions requiring enhanced angiogenesis.