Preparation and optimization of dextran-polycaprolactone nanoparticles with different molecular weight of polycaprolactone for effective dimethylcurcumin delivery

Key Points

• Effective dimethylcurcumin delivery occurs with optimized nanoparticles made from dextran and polycaprolactone.
• Optimal performance was achieved through varying the molecular weight of polycaprolactone, enhancing drug encapsulation.
• In vitro analysis demonstrated improved bioavailability and release profiles of the formulated nanoparticles.
• These findings may support further development of nanoparticle-based therapies for enhanced drug delivery.