PINK1 deacetylation by emodin-induced SIRT3 upregulation alleviates acute kidney injury by Inhibition of ferroptosis

Key Points

• Acute kidney injury is alleviated, highlighting the role of SIRT3 in mitigating ferroptosis.
• SIRT3 upregulation through emodin positively impacts PINK1 deacetylation.
• Inhibition of ferroptosis provides a protective effect on kidney cells during injury periods.
• Further exploration of this pathway could lead to new therapies for treating acute kidney injury.