Rabies virus matrix protein hijacks the TGF-beta activated kinase 1 binding protein 2-p38 mitogen-activated protein kinase pathway to inhibit apoptosis and promote viral replication | Synapse
March 3, 2026
Rabies virus matrix protein hijacks the TGF-beta activated kinase 1 binding protein 2-p38 mitogen-activated protein kinase pathway to inhibit apoptosis and promote viral replication
Key Points
The rabies virus matrix protein hinders apoptosis, enhancing viral replication within host cells.
Matrix protein engagement with the TGF-beta activated kinase 1 pathway was indicated by decreased apoptosis markers.
Observational analysis of cellular responses shows a direct interaction between the rabies viral components and host cellular pathways.
Understanding this interaction highlights potential therapeutic targets for managing rabies virus infections.