Discovery of tetrahydroisoquinoline derivatives as selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting activities and neuroprotective activities

Key Points

• Neurite outgrowth-promoting activity was observed with tetrahydroisoquinoline derivatives, enhancing neuronal growth.
• Selective inhibition of histone deacetylase 6 was identified, with supporting effects on neuroprotection and growth.
• Evaluated through in vitro assays, these compounds demonstrated promising neuroprotective properties in neuronal contexts.
• Findings highlight the potential of tetrahydroisoquinoline derivatives in developing new treatments for neurodegenerative disorders.