Perineuronal Net and Inhibitory Synapse Remodeling on Striatal Fast-spiking Interneurons by Chronic Alcohol Exposure

Key Points

• Chronic alcohol exposure rearranges inhibitory synapses and alters perineuronal nets in fast-spiking interneurons.
• Significant changes in synaptic structure indicate potential neuroplastic effects related to substance abuse.
• Analysis involving chronic exposure highlights the role of environmental factors on neurophysiological systems.
• Findings suggest major implications for understanding alcohol-related neural alterations and their effects on behavior.