Fibrillin-1 is a novel ligand of the epidermal growth factor receptor promoting mesangial cell activation and glomerulosclerosis

Key Points

• Mesangial cell activation was observed with fibrillin-1 exposure, suggesting a new pathway in glomerulosclerosis development.
• The study demonstrates that fibrillin-1 acts as a ligand for the epidermal growth factor receptor in renal cells.
• Assessment involving both in vitro and in vivo experiments highlighted the role of fibrillin-1 in cell signaling pathways.
• Findings suggest that targeting this interaction may provide new therapeutic options for patients with kidney disease.