Regioselective syntheses of 5-polyfluoroalkyl-3-hydroxyfuranes by oxidative cyclization of 6-polyfluoroalkyl-1-arylhexane-1,3,5-triones with hypervalent iodine(III) compounds

Key Points

• The synthesis achieves regioselective formation of 5-polyfluoroalkyl-3-hydroxyfuranes through oxidative cyclization.
• Utilizing hypervalent iodine(III) compounds results in a unique product formation profile, enhancing synthetic efficiency.
• The method showcases versatility in creating functionalized furanes from 6-polyfluoroalkyl-1-arylhexane-1,3,5-triones under controlled conditions.
• This approach may enable new applications in medicinal chemistry and materials science with further exploration.