Novel hydroxyacetimidamide derivatives of quinolin-4(1H)-one as dual inhibitor targeting AKR1B1/α-glucosidase for treatment of diabetic complications: Design, synthesis and biological evaluation

Key Points

• Dual inhibition of akr1b1 and alpha-glucosidase suggests effective treatment for diabetic complications.
• Key findings include novel hydroxyacetimidamide derivatives with promising inhibitory effects on both targets.
• Design and synthesis of derivatives were based on the structure of quinolin-4(1H)-one.
• Further evaluation may support the development of new therapies for diabetes-related issues.