Manganese concentrations in biological matrices and amyotrophic lateral sclerosis (ALS): a systematic review and meta-analysis

Key Points

• Manganese concentrations show significant associations with amyotrophic lateral sclerosis severity, indicating potential neurotoxic effects.
• The meta-analysis highlights a mean increase of manganese in ALS patients compared to healthy controls, supporting the hypothesis of toxicity.
• Systematic review compiles data from multiple studies, including varying biological matrices like blood and cerebrospinal fluid.
• This work underscores the need for further investigation into manganese's role in ALS development and progression.