Acid-catalyzed three-component bicyclization for the synthesis of quinazoline fused imidazole-2-thione derivatives with a tetrasubstituted carbon center

Key Points

• Quinazoline fused imidazole derivatives were successfully synthesized through a novel bicyclization process.
• This approach relies on an acid-catalyzed reaction, facilitating the formation of complex structures with a tetrasubstituted carbon center.
• The synthesis process demonstrated a high yield, underscoring its efficiency in producing desired compounds.
• Potential implications include advancements in pharmaceutical applications, warranting further exploration of this synthetic route.