Protective role of alkaloids of Calanthe fimbriata against ethanol-induced gastric ulcer in mice: Involvement of anti-gastric acid secretion and suppression of NF-κB/MAPK inflammatory cascades

Key Points

• Gastric ulcers are significantly reduced with alkaloid treatment, highlighting their protective role.
• The study shows a notable decrease in inflammatory markers nf-kb and mapk after alkaloid intervention.
• Assessment using ethanol-induced gastric ulcer models demonstrates effective anti-gastric acid secretion in treatment groups.
• Potential therapeutic applications exist, but further research is essential for clinical validation.